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青年研究员
朱元祥
发布时间:2024-03-25   作者:
学历 职称 副教授
研究方向 早期胚胎发育重大事件(母源-合子转换过程、原始生殖细胞PGC的发育分化)过程中的分子调控机理研究 Email


undefined基本信息

姓名:朱元祥

职称:副教授,硕士生导师

Email:zhuyuanxiang[at]ynu.edu.cn

 

教育经历

2004.09–2008.07    烟台大学,生物技术专业,获理学学士学位

2008.10–2016.09    中国科学院大学,发育生物学,获理学博士士学位

 

工作经历

2016.10–2020.08    博士后,中国科学院动物研究所

2020.09–2022.09    博士后,云南大学 生物医药研究院

2023.09–至今      副教授,云南大学,生物医药研究院

 

研究方向

一、基础研究:果蝇及斑马鱼早期发育调控机制研究

以斑马鱼、果蝇胚胎为研究对象,利用质谱、超高分辨显微成像、测序技术等手段研究早期胚胎发育重大事件(母源-合子转换过程、原始生殖细胞PGC的发育分化)过程中的分子调控机理。

二、应用研究:核酸类小分子药物开发

核酸类药物-反义寡核苷酸(ASO)药物的开发及应用。


代表性论文 

  1. Gao,Yajie#, Yuanxiang Zhu#, Qinmiao Sun, and Dahua Chen.Ribosome-associated protein quality control: Implications for neurodegenerative diseases and therapeutic potential. Science Bulletin. 2024-Jan-18

  2. Zhu Yuanxiang, Gao, Yajie, Qinmiao Sun, and Dahua Chen. A protocol for mimicking Lipid-mediated phase separation on the membrane using Giant unilamellar vesicles. STAR Protoc. 2022-sep-21

  3. Gao, Yajie#, Yuanxiang Zhu#, Qinmiao Sun, and Dahua Chen. Optimized protocols for RNA-induced silencing complex assembly and cleavage in cultured Drosophila cells. STAR Protoc. 2022 Jul 31;3(3)

  4. Gao, Yajie#, Yuanxiang Zhu#, Qinmiao Sun, and Dahua Chen. Argonaute-dependent ribosome-associated protein quality control. 2022 Aug 16. Trends in cell biology.

  5. Gao, Yajie#, Yuanxiang Zhu#, Hailong Wang#, Ying Cheng, Dongbo Zhao, Qinmiao Sun, and Dahua Chen. Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination. Molecular Cell. 2022;82(7):1313-+.

  6. Zhang, Guoqiang#, Yongru Xu#, Xiaona Wang#, Yuanxiang Zhu#, Liangliang Wang, Wenxin Zhang, Yiru Wang, Yajie Gao, Xuna Wu, Ying Cheng, Qinmiao Sun, and Dahua Chen. Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay. Nature Communications. 2022;13(1).

  7. Li, Zhu#, Yuan Xiang Zhu#, Li-Jun Gu, and Ying Cheng. Understanding autism spectrum disorders with animal models: applications, insights, and perspectives. Zoological Research. 2021;42(6):800-24.

  8. Liu Jianzhao#, Yuanxiang Zhu#, Guan-Zheng Luo#, Xinxia Wang#, Yanan Yue, Xiaona Wang, Xin Zong, Kai Chen, Hang Yin, Ye Fu, Dali Han, Yizhen Wang, Dahua Chen, and Chuan He. Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Nature Communications. 2016;7.

  9. Wang Weigang; Yang Na; Wang Liangliang; Zhu Yuanxiang; Chu Xiao; Xu Weijie; Li Yawei; Xu Yihai; Gao Lina; Zhang Beibei; Zhang Guoqiang; Sun Qinmiao; Wang Weihong; Wang Qiang; Zhang Wenxin; Chen Dahua. (2024). The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43 (3), pp.113873

  10. Yongfang Lin; Jing Yang; Qili Yang; Sha Zeng; Jiayu Zhang; Yuanxiang Zhu; Yuxin Tong; Lin Li; Weiqi Tan; Dahua Chen; Qinmiao Sun. PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling. Nature Communications, 2023, 14(1)

  11. Zhang Wenxin; Wang Liangliang; Zhao Yinjiao; Wang Yufei; Chen Chaoyang; Hu Yu; Zhu Yuanxiang; Sun Hao; Cheng Ying; Sun Qinmiao; Zhang Jian; Chen Dahua. (2022). Single-cell transcriptomic analysis of honeybee brains identifies vitellogenin as caste differentiation-related factor. iScience 25, 104643.

  12. Gu Haiyan, Jing Yang, Jiayu Zhang, Ying Song, Yao Zhang, Pengfei Xu, Yuanxiang Zhu, Liangliang Wang, Pengfei Zhang, Lin Li, Dahua Chen, and Qinmiao Sun. PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation. Nature Communications. 2022;13(1).

  13. Zhang Guoqiang, Hua Huang, Di Liu, Ying Cheng, Xiaoling Liu, Wenxin Zhang, Ruichuan Yin, Dapeng Zhang, Peng Zhang, Jianzhao Liu, Chaoyi Li, Baodong Liu, Yuewan Luo, Yuanxiang Zhu, Ning Zhang, Shunmin He, Chuan He, Hailin Wang, and Dahua Chen. N-6-Methyladenine DNA Modification in Drosophila. Cell. 2015;161(4):893-906.

  14. Sun, Qinmiao, Shoujun Huang, Xiaona Wang, Yuanxiang Zhu, Zhenping Chen, and Dahua Chen. N-6-methyladenine functions as a potential epigenetic mark in eukaryotes. Bioessays. 2015;37(11):1155-62.

  15. Huang, Shoujun, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao, and Dahua Chen. Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover. Plos Biology. 2013;11(11).

  16. Xia, Laixin, Shunji Jia, Shoujun Huang, Hailong Wang, Yuanxiang Zhu, Yanjun Mu, Lijuan Kan, Wenjing Zheng, Di Wu, Xiaoming Li, Qinmiao Sun, Anming Meng, and Dahua Chen. The Fused/Smurf Complex Controls the Fate of Drosophila Germline Stem Cells by Generating a Gradient BMP Response. Cell. 2010;143(6):978-90.


承担科研项目

  1. 云南省科技厅,基础研究和应用基础研究重大项目,202302AO370011,早期胚胎发育调控,2023-12 至 2027-11,300万元,在研,参与

  2. 云南省科技厅,顶尖团队项目,202305AT350003,纳米抗体及其衍生药物研发,2023-01 至2025-12,1500万元,在研,参与

  3. 云南省科技厅,团队专项,202305AS350022,云南省西南特色生物医药创新研究顶尖团队,2023-01 至2025-12,100万元,在研,参与