报告题目:从胚胎干细胞到生殖细胞:一个目标,多重调控
报 告 人:陈迪 研究员(浙江大学)
报告时间:2020年12月28日 (星期一)14:00-16:00
报告地点:云南大学呈贡校区力行楼1301
个人简介:
陈迪,浙江大学爱丁堡大学联合学院,研究员。实验室主要通过前沿的胚胎干细胞三维分化模型,致力于从单细胞水平研究人类早期胚胎发育过程中细胞命运决定和维持的生物学基础,以及参与调控体内胚胎发育和体外胚胎干细胞诱导分化的遗传和表观遗传调控机制研究。
代表性论文:
Chen, D.*, Liu, W.*, Zimmerman, J., Pastor, W., Kim, R., Hosohama, L., Ho, J., Aslanyan, M., Gell, J.,Jacobsen, S., Clark, A. (2018). The TFAP2C-regulated OCT4 naïve enhancer is involved in human germline formation. Cell Report 25, 3591-3602.
Hancock, G. and Chen, D. (2018). Another step closer to unlocking specification of primordial germ cells. AME Medical Journal 3, 64.
Chen, D. and Clark, A. (2018). Mitochondrial DNA selection in human germ cells. Nature Cell Biology 20, 118-120.
Pastor, W.A.*, Chen D.*, Liu, W.*, Kim R., Sahakyan, A., Lukianchikov, A., Plath, K., Jacobsen, S.E. and Clark, A.T. (2015). Naïve human pluripotent cells feature a methylation landscape devoid of blastocyst or germline memory. Cell Stem Cell 18, 323-329.
Chen, D.*, Wu, C.*, Zhao, S., Geng, Q., Gao, Y., Li, X., Zhang, Y., Wang, Z. (2014). Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila.PLoS Genetics 10, e1004797.