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PI
陈大华
发布时间:2020-03-21   作者:
学历 博士研究生 职称 教授
研究方向 主要以果蝇、斑马鱼和小鼠等为模型,系统地研究生殖细胞发育和成体干细胞命运的调控机制 Email


基本信息

姓名:陈大华

职务:院长

职称:教授,博士生导师

Email:chendh[at]ynu.edu.cn

 

教育经历

1987.09-1991.07   安徽农业大学,获理学学士学位

1993.09-1996.07   中国农业大学,获理学硕士学位

1996.09-1999.07   中国科学院植物研究所,获理学博士学位

 

科研经历

1999.09-2000.08   博士后,美国肯塔基大学

2000.09-2003.09   博士后,美国得州大学西南医学中心

2003.09-2005.06   Instructor,美国得州大学西南医学中心

 

工作经历

2005.05-2020.05   中国科学院动物所,膜生物学国家重点实验室副主任

2020.05-至今     云南大学生物医药研究院院长

 

研究方向:

主要以果蝇、斑马鱼和小鼠等为模型,系统地研究生殖细胞发育和成体干细胞命运的调控机制,在发育生物学领域取得了重要的学术成就,在Cell、 Mol CellNature NeuroscienceDev Cell、PLoS BiolJCBCurr Biol等主流杂志上发表一系列研究性论文,在国内外产生了重要的影响。

 

代表性论文:

1.   Gao Y, Zhu Y, Sun Q, Chen D. Argonaute-dependent ribosome-associated protein quality control. Trends Cell Biol. 2023 Mar;33(3):260-272.

2.   Zhang G, Xu Y, Wang X, Zhu Y, Wang L, Zhang W, Wang Y, Gao Y, Wu X,Cheng Y, Sun Q*, Chen D*. 2022. Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay. Nature Communications. 13(1):859.

3. Gao Y, Zhu Y, Wang H, Cheng Y, Zhao D, Sun Q*, and Chen D*. 2022. Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination. Molecular Cell 82. Cover. 

4. Haiyan Gu, Jing Yang, Jiayu Zhang, Ying Song, Yao Zhang, Pengfei Xu, Yuanxiang Zhu, Liangliang Wang, Pengfei Zhang, Lin Li, Dahua Chen* & Qinmiao Sun*.2022.PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation. Nature Communications 13, 1564. 

5.   Ji S, Luo Y, Cai Q, Cao Z, Zhao Y, Mei J, Li C, Xia P, Xie Z, Xia Z, Zhang J, Sun Q* and Chen D*. 2019. LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan. Mol Cell. 74:363-377.

6.   He S, Zhang G, Wang J, Gao Y, Sun R, Cao Z, Chen Z, Zheng X, Yuan J, Luo Y, Wang X, Zhang W, Zhang P, Zhao Y, He C, Tao Y*, Sun Q* and Chen D*. 2019. 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda. Nature Communications. 10:2219.

7.   Cheng Y, Wang ZM, Tan W, Wang X, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, Zhou Z, Liu A, Tang GB, Liu C, Dai ZJ, Wang YY, Wang H, Wang X, Kang Y, Lin L, Chen Z, Xie N, Sun Q, Xie W, Peng J, Chen D*, Teng ZQ* and Jin P*. 2019 Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nature Neuroscience. 21:1689-1703.

8.   Li W, Li W, Zou L, Ji S, Li C, Liu K, Zhang G, Sun Q*, Xiao F* and Chen D*. 2017 Membrane targeting of inhibitory Smads through palmitoylation controls TGF-beta/BMP signaling. PNAS. 114:13206-13211.

9.   Ji S, Li C, Hu L, Liu K, Mei J, Luo Y, Tao Y, Xia Z, Sun Q* and Chen D*. 2017 Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A. PNAS. 201619188.

10.   Liu J, Zhu Y, Luo G-Z, Wang X, Yue Y, Wang X, Zong X, Chen K, Yin H, Fu Y, Han D, Wang Y, Chen D* and He C*. 2016 Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Nature Communications. 7:13052.

11.   Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, Yang M, Sun L, Li L, Wang H, Chen D* and Sun Q*.2016 Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nature Communications. 7:11848.

12.   Zhang G, Huang H, Liu D, Cheng Y, Liu X, Zhang W, Yin R, Zhang D, Zhang P, Liu J, Li C, Liu B, Luo Y, Zhu Y, Zhang N, He S, He C, Wang H* and Chen D*. 2015 N(6)-methyladenine DNA modification in Drosophila. Cell. 161:893-906.

13.   Sun Q, Huang S, Wang X, Zhu Y, Chen Z and Chen D*. 2015 N(6) -methyladenine functions as a potential epigenetic mark in eukaryotes. BioEssays : news and reviews in molecular, cellular and developmental biology. 37:1155-62.

14.  Li C, Kan L, Chen Y, Zheng X, Li W, Zhang W, Cao L, Lin X, Ji S, Huang S, Zhang G, Liu X, Tao Y, Wu S* and Chen D*. 2015 Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation. Cell Research. 25:1152-70.

15.  Zhu G, Li Y, Zhu F, Wang T, Jin W, Mu W, Lin W, Tan W, Li W, Street RC, Peng S, Zhang J, Feng Y, Warren Stephen T, Sun Q*, Jin P* and Chen D*. 2014 Coordination of Engineered Factors with TET1/2 Promotes Early-Stage Epigenetic Modification during Somatic Cell Reprogramming. Stem Cell Reports. 2:253-261.

16.  Zhang W, Cheng Y, Li Y, Chen Z, Jin P* and Chen D*. 2014 A feed-forward mechanism involving Drosophila fragile X mental retardation protein triggers a replication stress-induced DNA damage response. Human Molecular Genetics. 23:5188-96.

17.  Wang H, Huang H and Chen D*. 2014 Effective gene knockdown in the Drosophila germline by artificial miRNA-mimicking siRNAs. Methods in Molecular Biology. 1093:225-34.

18.  Ji S, Sun M, Zheng X, Li L, Sun L, Chen D* and Sun Q*. 2014 Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila. Nature Communications.5:3458.

19.  Huang H, Li Y, Szulwach KE, Zhang G, Jin P* and Chen D*. 2014 AGO3 Slicer activity regulates mitochondria-nuage localization of Armitage and piRNA amplification. The Journal of Cell Biology. 206:217-30.

20.  Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y* and Chen D*. 2013 Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. PLoS Biology. 11:e1001721.

21.  Xia L, Zheng X, Zheng W, Zhang G, Wang H, Tao Y* and Chen D*. 2012 The niche-dependent feedback loop generates a BMP activity gradient to determine the germline stem cell fate. Curr Biol.22:515-21.

22.  Tan H, Poidevin M, Li H, Chen D* and Jin P*. 2012 MicroRNA-277 modulates the neurodegeneration caused by Fragile X premutation rCGG repeats. PLoS Genetics.8:e1002681.

23.  Lu C, Lin L, Tan H, Wu H, Sherman SL, Gao F, Jin P* and Chen D*. 2012 Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice. Human Molecular Genetics. 21:5039-47.

24.  Wang H, Mu Y and Chen D*. 2011 Effective gene silencing in Drosophila ovarian germline by artificial microRNAs. Cell Research. 21:700-3.

25.  Xia L, Jia S, Huang S, Wang H, Zhu Y, Mu Y, Kan L, Zheng W, Wu D, Li X, Sun Q, Meng A and Chen D*. 2010 The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response. Cell. 143:978-90.

26.  Yang Y, Xu S, Xia L, Wang J, Wen S, Jin P and Chen D*.2009 The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genetics. e1000444.

27.  Chen D, Wang Q, Huang H, Xia L, Jiang X, Kan L, Sun Q and Chen D*. 2009 Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila. Development (Cambridge, England).;136:4133-42.

28.  Jiang X, Xia L, Chen D, Yang Y, Huang H, Yang L, Zhao Q, Shen L, Wang J and Chen D*. Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes. Developmental Cell. 2008;14:494-506.

29.  Yang L, Duan R, Chen D, Wang J, Chen D and Jin P. Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila. Human Molecular Genetics. 2007;16:1814-20.

30.  Yang L, Chen D, Duan R, Xia L, Wang J, Qurashi A, Jin P and Chen D. Argonaute 1 regulates the fate of germline stem cells in Drosophila. Development(Cambridge, England). 2007;134:4265-72.

31.  Chen D and McKearin D. Gene circuitry controlling a stem cell niche. Curr Biol.2005;15:179-84.

32.  Chen D and McKearin DM. A discrete transcriptional silencer in the bam gene determines asymmetric division of the Drosophila germline stem cell. Development (Cambridge, England). 2003;130:1159-70.


 

 

承担科研项目:

1.   卵子发生和胚胎发育基础科学研究中心,国家基金委,2020/01-2024-12,直接经费:1600万

2.   国家重点研发计划,2018YFC1003301,筛选参与生殖质形成、原始生殖细胞特化、迁移、归巢和分化调控的关键基因及其功能研究,2018/12-2021/12,323万元,在研,项目首席

3.   国家自然科学基金重大研究计划重点支持项目,91640204,小分子RNA介导的基因沉默协同调控泛素化蛋白降解的机制研究,2017/01-2020/12,直接经费270万,在研,项目首席

4.   中国科学院战略性先导科技专项(B 类),XDB19000000,细胞命运可塑性的分子基础与调控,2017/01-2019/12,三年滚动经费~200万,在研,骨干

5.   国家自然科学基金重大项目,31590831,RNA 结合蛋白在斑马鱼生殖细胞形成和发育及精子发生中的作用机制,2016/01-2020/12,直接经费325万,在研,主持

6.   中国科学院创新交叉团队项目,新型 DNA 6mA 表观遗传修饰的发育调控机制研究,2016/01-2018/12,100万,已结题,主持

7.   中国科学院-日本学术振兴会合作项目,泛素化修饰与转录调控决定干细胞命运的研究, 2015/04-2018/03,45万,已结题,主持

8.   国家重大科学研究计划,2013CB945000,原始生殖细胞发生和性腺发育的机制研究,2013/01-2017/12,333万,已结题,项目首席,主持

9.   国家自然科学基金重点项目,31130036,果蝇生殖细胞发育翻译调控机制的研究,2012/01-2016/12,290万,已结题,主持

10.  中国科学院干细胞先导专项,XDA01010306,干细胞与微环境的相互作用,2011/01-2015/12,767.95万,已结题,主持

11.  国家自然科学基金重大研究计划重点支持项目,91019022,细胞编程和重编程的表观遗传机制-果蝇原始生殖细胞发育的表观遗传分子机制研究,2011/01-2014/12,200万,已结题,主持

12.  国家自然基金杰出青年基金项目,30825026,生殖干细胞命运调控机制,2009/01-2012/12,200万,已结题,主持

 

奖项荣誉:

1.   2016年度“中国科学院杰出科技成就奖”

2.   2016年新世纪百千万人才工程国家级人选、教育部长江学者计划特聘教授

3.   2016年科技部“万人计划”领军人才

4.   2013年享受国务院政府特殊津贴

5.   2008年国家杰出青年科学基金获得者

6.   2016年“谈家祯生命科学创新奖

7.   2015年“中科院优秀导师奖”

8.   2008年“朱李月华奖”

9. 2022年“云南省五一劳动奖章”

10. 2022年云南大学“红云园丁奖--卓越教师奖” 


学术兼职:

1.   2019年担任科技部重大研究计划首席科学家

2.   2015年担任基金委重大项目首席科学家

3.   2015年担任中科院创新交叉团队首席科学家

4.   2013年担任科技部重大研究计划首席科学家

5.   任多个期刊的编委成员,是国际主流学术刊物Mol CellCurr BiolPNASJCBEMBO JDevelopmentHum Mol GenetMol Biol CellGenesisJGG等杂志审稿人。