报告题目：早期胚胎发育的基因组稳态调控
报 告 人：郑萍 研究员（中科院昆明动物所）
报告时间：2021年10月14日（星期四）14:00-16:00
报告地点：云南大学呈贡校区力行楼1301
个人简介：
郑萍，中国科学院昆明动物研究所研究员，博士生导师，中国科学院“王宽诚西部学者突出贡献奖”、云南省三八红旗手称号获得者。多年来主要以猕猴和小鼠为研究对象，从事哺乳动物生殖和早期胚胎发育研究并取得重要进展，为该领域理论研究和实践应用作出重要贡献。主要兴趣包括：1）干细胞维持基因组稳定性的特征和分子调控研究；2）生殖干细胞的基础和应用研究；3）灵长类早期胚胎发育。
代表性论文：
Wang L # , Li J # , Zhou H, Zhang W, Gao J, Zheng P*. A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability. Nature Communications, 2021, 12(1):5572.
Li JZ, Shang YF, Wang L, Zhao B, Sun CL, Li JL, Liu SL, Li C, Tang M, Meng FL*, Zheng P*. Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia. Science Advances, 2020, 6(44):eaba0682.
Ma H#, Zhai J#, Wan H#, Jiang X#, Wang X, Wang L, Xiang Y, He X, Zhao ZA, Zhao B, Zheng P*, Li L*, Wang H*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science, 2019, 366(6467):eaax7890.
Zhang WD#, Chen ZL#, Zhang DF, Zhao B, Liu L, Xie ZY, Yao YG, Zheng P*. KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells. PLoS Biology, 2019, 17(10):e3000468.
Liu D#, Wang X#, He D#, Sun C#, He X, Yan L, Li Y, Han JJ*, Zheng P*. Single-cell RNA-sequencing reveals the existence of naive and primed pluripotency in pre-implantation rhesus monkey embryos. Genome Research, 2018, 28 (10):1481–1493. (封面论文)
Zhao B#, Zhang WD#, Cun YX, Li JZ, Liu Y, Gao J, Zhu HW, Zhou H, Zhang RG, Zheng P*. Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia Floped protein complex. Cell Research, 2018, 28(1):69-89.
