基本信息

姓名：章文信

职称：副教授，硕士生导师

Email：zhangwx[at]ynu.edu.cn

教育经历

2008.09–2012.07   安徽师范大学，生物科学（师范）专业，获理学学士学位

2012.09–2018.01   中国科学院动物研究所，发育生物学专业，硕博连读，获理学博士学位

工作经历

2020.07–2023.05   云南大学，生物医药研究院，博士后

2023.06- 至今      云南大学，生物医药研究院，副教授，“东陆人才计划青年学者”岗位

研究方向

一、基础研究：主要以蜜蜂为模型，利用多组学联合分析结合大规模遗传筛选，研究社会性昆虫的发育过程以及社会行为调控机制。

二、应用研究：健康产品研发；生物大分子药物研发。

发表论文

 (^# 第一作者; * 通讯作者)

1.  Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W*., Wang, Q.*, Zhang, W.*, & Chen, D.* (2024). The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports, 43(3), 113873. Advance online publication.

2.  Zhang, W.#, Wang, L. #, Zhao, Y. #, Wang, Y. #, Chen, C., Hu, Y., Zhu, Y., Sun, H., Cheng, Y., Sun, Q., Zhang, J.*, & Chen, D.* (2022). Single-cell transcriptomic analysis of honeybee brains identifies vitellogenin as caste differentiation-related factor. iScience, 25(7), 104643.

3.  Zhang, G., Xu, Y., Wang, X., Zhu, Y., Wang, L., Zhang, W., Wang, Y., Gao, Y., Wu, X., Cheng, Y., Sun, Q., & Chen, D. (2022). Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay. Nature Communications, 13(1), 859.

4.  Wang, Y., Zhang, W., Shi, T., Xu, S., Lu, B., Qin, H., & Yu, L. (2020). Synergistic toxicity and physiological impact of thiamethoxam alone or in binary mixtures with three commonly used insecticides on honeybee. Apidologie, 51(3), 395-405.

5.  Wang, Y., Sheng, Y., Liu, Y., Zhang, W., Cheng, T., Duan, L., Pan, B., Qiao, Y., Liu, Y., & Gao, S. (2019). A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N6-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription. Nucleic Acids Research, 47(22), 11771–11789.

6.  He, S., Zhang, G., Wang, J., Gao, Y., Sun, R., Cao, Z., Chen, Z., Zheng, X., Yuan, J., Luo, Y., Wang, X., Zhang, W., Zhang, P., Zhao, Y., He, C., Tao, Y., Sun, Q., & Chen, D. (2019). 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda. Nature Communications, 10(1), 2219.

7.  Shi, T., Burton, S., Wang, Y., Xu, S., Zhang, W., & Yu, L. (2018). Metabolomic analysis of honey bee, Apis mellifera L. response to thiacloprid. Pesticide Biochemistry and Physiology, 152, 17-23.

8. Yao, B., Cheng, Y., Wang, Z., Li, Y., Chen, L., Huang, L., Zhang, W., Chen, D., Wu, H., Tang, B., & Jin, P. (2017). DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress. Nature Communications, 8(1), 1122.

9.  Li, C., Kan, L., Chen, Y., Zheng, X., Li, W., Zhang, W., Cao, L., Lin, X., Ji, S., Huang, S., Zhang, G., Liu, X., Tao, Y., Wu, S., & Chen, D. (2015). Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation. Cell Research, 25(10), 1152–1170.

10.  Zhang, G., Huang, H., Liu, D., Cheng, Y., Liu, X., Zhang, W., Yin, R., Zhang, D., Zhang, P., Liu, J., Li, C., Liu, B., Luo, Y., Zhu, Y., Zhang, N., He, S., He, C., Wang, H., & Chen, D. (2015). N6-methyladenine DNA modification in Drosophila. Cell, 161(4), 893–906.

11.  Zhang, W.#, Cheng, Y.#, Li, Y., Chen, Z., Jin, P.*, & Chen, D*. (2014). A feed-forward mechanism involving Drosophila fragile X mental retardation protein triggers a replication stress-induced DNA damage response. Human Molecular Genetics, 23(19), 5188-5196.

承担科研项目

1. 云南省科技厅，基础研究和应用基础研究重大项目，202302AO370011，早期胚胎发育调控，2023-12 至 2027-11，300万元，在研，参与

2. 云南省科技厅，顶尖团队项目，202305AT350003，纳米抗体及其衍生药物研发，2023-01 至2025-12，1500万元，在研，参与

3. 云南省科技厅，团队专项，202305AS350022，云南省西南特色生物医药创新研究顶尖团队，2023-01 至2025-12，100万元，在研，参与

4. 云南省科技厅，202105AB160002，生殖质组分的解析以及诱导类原始生殖细胞重编程体系的开发，2021-01 至 2025-12，972万元，在研，参与

5. 国家自然科学基金委员会，面上项目，82071540，精神疾病风险基因MIR137在调节小胶质细胞功能介导孤独症发生中的作用与机制研究，2021-01至 2024-12，55万元，在研，参与